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Backgrounds: Intellectual Disability students must be able to master the practice of personal hygiene during menstruation skills. However, to teach this skill to them is not easy. They need certain methods to learn these skills to get effective results. Video-Based Instruction is one method to teach these skills. This study aims to determine whether there is an effect of Video-Based Instruction on the practice of personal hygiene during menstruation on Intellectual Disability students. Methods: This is quantitative research with pre-experimental type and one group pretest-posttest design. The data collection tool is a "personal hygiene" questionnaire. The data analysis method uses a paired sample t-test with the help of SPSS version 25. This research conducted at SLB Negeri 3 Central Jakarta with a total sample is 20 respondents selected by the purposive sampling technique. Results: Most respondents were 14 years old (20%), 7th grade (30%), get menarche at 12 and 13 years (25%). The mean score for the practice of personal hygiene during menstruation pre-test is 41.30 and post-test is 53.20. Paired sample t-test results showed that sig. (2-tailed) <0.001. Conclusion: The results showed that it received Ha, which means that there is an effect of Video-Based Instruction on the practice of personal hygiene during menstruation on Intellectual Disabilities students. The results also showed that there are mean score differences of the pre-test and post-test results, which is an increase in the mean score of the post-test results by 11,90.